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April 11.2025
3 Minutes Read

Discover Real-World Efficacy of Ranieyes: Lupin’s Ranibizumab Biosimilar

Close-up of syringe held by gloved hand, efficacy of Ranieyes Ranibizumab Biosimilar.

Understanding Ranieyes: An Innovative Biosimilar

In the realm of eye care, the development and approval of biosimilars represent a significant advancement in treatment options for retinal conditions. Lupin Ltd's Ranieyes, a biosimilar of Ranibizumab, was introduced to meet the growing need for affordable and effective therapies for conditions like Diabetic Macular Edema (DME) and Neovascular Age-Related Macular Degeneration (nAMD). Manufactured in India and approved for various ocular conditions, Ranieyes has been available since 2021, fostering hope among countless patients in need of cutting-edge treatments.

Key Findings from the BRESER Study

The recently published BRESER Study, led by Dr. Ashish Sharma and reported in the American Society of Retina Specialists journal, provides crucial insights into the real-world efficacy and safety of Ranieyes. Conducted across seven eye care centers in India, this comprehensive, multicenter, observational study examined 474 biosimilar injections administered to 268 eyes of 254 patients.

Patients received at least one 0.5mg intravitreal injection of Ranieyes for indications such as DME, macular neovascularization (MNV), and retinal vein occlusion (RVO). The study reflects rigorous patient follow-ups over a mean duration of 7.7 weeks, focusing on how effectively Ranieyes improved vision and reduced central subfield thickness (CST).

Encouraging Outcomes: Vision Improvement and Safety

One of the most compelling results from the BRESER Study is the significant increase in Best-Corrected Visual Acuity (BCVA) recorded among different patient groups. For patients with DME, the mean logMAR BCVA improved from 0.77 ± 0.37 (6/36) at baseline to 0.43 ± 0.25 (6/15) at follow-up. Patients suffering from MNV and RVO also experienced marked improvements in their visual acuity, showcasing the efficacy of Ranieyes.

Furthermore, the study reported significant reductions in CST across the patient groups, bolstering the claim that Ranieyes is a safe and effective treatment option. The reduction in CST points to the drug’s ability to facilitate healthier retinal conditions, an essential factor in managing diseases like DME.

Broader Implications for Eye Care

The findings from the BRESER Study illuminate Ranieyes’ potential to become a mainstay in the treatment of sight-threatening conditions, particularly in developing nations where healthcare budgets may restrict access to costly therapies like the original Lucentis. This study reassures practitioners of the biosimilar’s efficacy, potentially leading to wider adoption and enhancing patient outcomes.

Furthermore, as healthcare systems globally continue to strive for more sustainable options, biosimilars like Ranieyes can relieve financial pressures while maintaining high standards of care. This aligns with a broader trend in healthcare aiming to provide more accessible treatments without compromising quality.

Looking Ahead: Future of Biosimilars in Ophthalmology

The success demonstrated in the BRESER Study marks not just a victory for Ranieyes, but a potential turning point for the biosimilar market in ophthalmology. It raises questions about how other biosimilars might follow in its footsteps, especially in expanding the range of treatments available for various eye diseases.

With growing evidence supporting the safety and effectiveness of biosimilars, researchers and healthcare providers can look to future studies to evaluate long-term outcomes and explore the full range of benefits these treatments can provide. The continuous evolution of biosimilars may lead to more innovative solutions that make a meaningful difference in patients' lives.

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01.09.2026

Could Insufficient Sleep Be Reducing Your Life Expectancy?

Update Understanding the Impact of Insufficient Sleep on Longevity Recent research underscores a sobering reality: insufficient sleep is not just uncomfortable; it might also be a key factor in reducing life expectancy. A significant study from the Oregon Health & Science University (OHSU) emphasizes the urgent need for prioritizing sleep as a crucial health behavior, showing that getting fewer than seven hours of sleep per night is associated with lower life expectancy, overshadowing even diet and exercise in its implications. The Strength of the Connection Between Sleep and Life Expectancy Andrew McHill, a lead author from OHSU, expressed surprise at the strength of this association, which was revealed through extensive analysis of CDC data spanning several years. The findings indicate that sleep deprivation correlates strongly with higher mortality risk across almost all U.S. counties studied. What’s particularly striking is that the harmful effects of insufficient sleep exceed those associated with lifestyle factors such as diet, physical activity, and even social isolation. A Deeper Dive into the Biological Impacts of Sleep Deprivation Sleep’s role in maintaining health is vast, influencing everything from mental clarity to cardiovascular health. During sleep, the body undergoes significant restorative processes. It repairs tissues, consolidates memories, and regulates critical hormones. A lack of adequate sleep disrupts these processes, potentially leading to increased body fat, elevated blood pressure, and impaired insulin sensitivity. Each of these factors raises the risk of conditions such as obesity, diabetes, and heart disease—all of which can shorten life expectancy. Societal Implications of Sleep Deprivation Dr. Virend Somers, a cardiologist at the Mayo Clinic, pointed out that men who achieve sufficient sleep live, on average, about five years longer than their sleep-deprived counterparts, while women enjoy a two-year advantage. These differences illustrate not only the personal health implications but also a broader societal concern, as public health initiatives may need to emphasize better sleep hygiene as part of their wellness strategies. Strategies to Improve Sleep Quality Fortunately, improving sleep quality is often within our control. Here are some strategies: Establish a Consistent Routine: Going to bed and waking up at the same time every day helps regulate your body’s internal clock. Create a Sleep-Inducing Environment: Keep your sleeping area dark, cool, and quiet to encourage the best possible sleep. Avoid Stimulants: Minimizing caffeine and electronic device usage in the hours leading up to bedtime can enhance your sleep quality. Regular Exercise: Engaging in moderate physical activity during the day can help promote deeper sleep at night. Mindfulness Techniques: Practices like meditation or gentle yoga can help calm the mind and prepare the body for rest. Future Predictions for Sleep Research The growing body of evidence linking sleep with overall health is leading to promising future directions in research. Scientists are increasingly focused on understanding the mechanisms by which sleep influences physical health and utilizing this knowledge to mitigate health risks associated with insufficient sleep. As we continue to learn more, integrating sleep health into public health policies and individual health practices could transform our approach to longevity. Conclusion: The Holistic View of Health The implications of the OHSU study cannot be overstated: prioritizing sufficient sleep is as crucial as paying attention to diet and physical activity. In a society often valuing busyness over rest, this research highlights the necessity of recognizing sleep as a foundational pillar of health. The universal truth remains—getting adequate, quality sleep is essential not only for how we feel today but also for how long we will live healthily. For everyone seeking a longer, healthier life, it’s time to embrace sleep for what it truly is: a vital necessity.

01.08.2026

The Impact of Trademark Enforcement in Pharma: Lessons from ZERODOL Case

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01.07.2026

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